David G Soergel Selected Research

Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH

2/2018	Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF.
3/2015	Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure).
9/2013	First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers.
9/2012	TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.
11/2011	Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

David G Soergel Research Topics

Disease

8	Heart Failure 12/2019 - 11/2011
6	Pain (Aches) 01/2022 - 09/2014
6	Acute Pain 01/2020 - 03/2014
3	Nausea 01/2019 - 09/2014
3	Postoperative Pain 01/2019 - 01/2017
3	Vomiting 01/2019 - 09/2014
2	Dyspnea (Shortness of Breath) 08/2017 - 03/2015
2	Respiratory Insufficiency (Respiratory Failure) 09/2014 - 03/2014
1	Body Weight (Weight, Body) 01/2018
1	Hypercapnia 09/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2013
1	Cardiomegaly (Heart Hypertrophy) 09/2013

Drug/Important Bio-Agent (IBA)

12	LigandsIBA 01/2019 - 11/2011
7	Morphine (MS Contin)FDA LinkGeneric 01/2020 - 03/2014
7	GTP-Binding Proteins (G-Protein)IBA 01/2019 - 09/2013
7	((3- methoxythiophen- 2- yl)methyl)((2- (9- (pyridin- 2- yl)- 6- oxaspiro(4.5)decan- 9- yl)ethyl))amineIBA 01/2019 - 09/2014
6	Analgesics (Analgesic Drugs)IBA 01/2022 - 03/2014
6	Opioid Receptors (Opioid Receptor)IBA 01/2019 - 09/2014
5	Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OHIBA 02/2018 - 11/2011
3	Opioid Analgesics (Opioids)IBA 01/2019 - 09/2014
3	ArrestinIBA 09/2013 - 11/2011
3	Angiotensin IIIBA 09/2013 - 11/2011
2	Type 1 Angiotensin ReceptorIBA 02/2018 - 08/2017
1	Oxycodone (Oxycontin)FDA LinkGeneric 01/2022
1	ReninIBA 12/2019
1	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2018
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 03/2015
1	Brain Natriuretic Peptide (Natrecor)FDA Link 03/2015
1	Pharmaceutical PreparationsIBA 09/2014
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2013
1	Losartan (Cozaar)FDA LinkGeneric 09/2013
1	sarcosine- arginyl- valyl- tyrosyl- lysyl- histidyl- prolyl- alanineIBA 09/2013
1	CalciumIBA 09/2013
1	SodiumIBA 09/2013
1	Furosemide (Lasix)FDA LinkGeneric 09/2012

Therapy/Procedure

4	Analgesia 01/2019 - 09/2014
3	Therapeutics 08/2017 - 10/2013
2	Abdominoplasty 01/2019 - 01/2017
2	Length of Stay 08/2017 - 03/2015
1	Patient-Controlled Analgesia (Analgesia, Patient Controlled) 01/2017
1	Patient Readmission 03/2015